PRINCIPLES OF THE 3RS AND ARRIVE GUIDELINES IN ANIMAL RESEARCH

Principles of the 3Rs and ARRIVE Guidelines in Animal Research

The use of animals in research has concerned the general public and thoughtful researchers for a long time.For improved animal welfare and increased research quality, researchers have moral obligations to include the 3Rs.The Three Rs are basic principles of humane experimental technique that were first set skull bride and groom out by Russell and B

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Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models

Abstract Background Radix Puerariae is used in Chinese medicine to treat alcohol addiction and intoxication.The present study investigates the effects of Flos puerariae lobatae water extract (FPE) and its active ingredient puerarin on alcoholism using rodent models.Methods Alcoholic animals were given FPE or puerarin by oral intubation prior or aft

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Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC

Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Allergens (NDA) was asked to deliver an opinion on nicotinamide riboside chloride as a novel food (NF) pursuant to Regulation (EU) 2015/2283, including an evaluation of the safety of its use in food supplements as a source of niacin, and the bio

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